Journal article
Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children
DA Oyong, JR Loughland, MSF Soon, JA Chan, D Andrew, BD Wines, PM Hogarth, SD Olver, AD Collinge, A Varelias, JG Beeson, E Kenangalem, RN Price, NM Anstey, G Minigo, MJ Boyle
Ebiomedicine | Published : 2022
Abstract
Background: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell activation associated with antibody development in malaria. Whether Tfh cell activation in malaria is age dependent is unknown and no studies have compared Tfh cell activation in children and adults with malaria. Methods: We undertook a comprehensive study of Tfh cells, along with B cells and antibody induction in children and adults with malaria. Activation and proliferation of circulating Tfh (cTfh..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
We thank the Australian Red Cross Blood Service for providing malaria nayve samples and RBC for parasite culture. We thank Robin Anders (La Trobe University) for the generous supply of recombinant PfMSP2-3D7. We thank staff of the Papuan Health and Community Development Foundation, and all staff and teams involved in the studies. We thank Ammar Aziz for providing bioinformatics support. This work was supported by the National Health and Medical Research Council of Australia (International Collaborative Research Grant 283321; Early Career Fellowship 1125656 and Career Development Award 1141278, Project Grant 1145303 to PMH and BW, and Project Grant 1125656 to MJB; Senior Principal Research Fellowship 1135820 to NMA; Program Grants 290208 and 1132975; Investigator Grant 1173046 to JGB); Wellcome Trust (International Collaborative Research Grant ME928457MES; Senior Fellowship 200909 to RNP); Charles Darwin University (PhD scholarship to DAO), Menzies School of Health Research (PhD top-up award to DAO), The Australian Centre of Research Excellence in Malaria Elimination (ACREME) (Training award to DAO), Channel 7 Children's Research Foundation (grant to MJB and GM) and National Health Institute (grant 5RO1 A1041764-08). The Burnet Institute is supported by the National Health and Medical Research Council for Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support.